HDAC2 negatively regulates memory formation and synaptic plasticity

Chromatin modifications, especially histone-tail acetylation, have been implicated in memory formation. Increased histone-tail acetylation induced by inhibitors of histone deacetylases (HDACis) facilitates learning and memory in wildtype mice as well as in mouse models of neurodegeneration. Harnessi...

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Bibliografiska uppgifter
Huvudupphovsmän: Guan, Ji-Song, Haggarty, Stephen J., Giacometti, Emanuela, Dannenberg, Jan-Hermen, Joseph, Nadine, Gao, Jun, Nieland, Thomas J.F., Zhou, Ying, Wang, Xinyu, Mazitschek, Ralph, Bradner, James E., DePinho, Ronald A., Jaenisch, Rudolf, Tsai, Li-Huei
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2009
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3498958/
https://ncbi.nlm.nih.gov/pubmed/19424149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature07925
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