Patterns of scAAV Vector Insertion Associated With Oncogenic Events in a Mouse Model for Genotoxicity

Recombinant adeno-associated virus (rAAV) vectors have gained an extensive record of safety and efficacy in animal models of human disease. Infrequent reports of genotoxicity have been limited to specific vectors associated with excess hepatocellular carcinomas (HCC) in mice. In order to understand...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Rosas, Lucia E, Grieves, Jessica L, Zaraspe, Kimberly, La Perle, Krista MD, Fu, Haiyan, McCarty, Douglas M
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group 2012
Aiheet:
Original Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3498805/
https://ncbi.nlm.nih.gov/pubmed/22990674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.197
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia