Patterns of scAAV Vector Insertion Associated With Oncogenic Events in a Mouse Model for Genotoxicity

Recombinant adeno-associated virus (rAAV) vectors have gained an extensive record of safety and efficacy in animal models of human disease. Infrequent reports of genotoxicity have been limited to specific vectors associated with excess hepatocellular carcinomas (HCC) in mice. In order to understand...

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Autores principales: Rosas, Lucia E, Grieves, Jessica L, Zaraspe, Kimberly, La Perle, Krista MD, Fu, Haiyan, McCarty, Douglas M
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2012
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3498805/
https://ncbi.nlm.nih.gov/pubmed/22990674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.197
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