Up-regulation of brain-derived neurotrophic factor is regulated by extracellular signal-regulated protein kinase 5 and by nerve growth factor retrograde signaling in colonic afferent neurons in colitis

Brain-derived neurotrophic factor (BDNF) plays an essential role in sensory neuronal activation in response to visceral inflammation. Here we report that BDNF up-regulation in the primary afferent neurons in the dorsal root ganglia (DRG) in a rat model of colitis is mediated by the activation of end...

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Bibliographische Detailangaben
Hauptverfasser: Yu, Sharon J, Grider, John R, Gulick, Melisa A, Xia, Chun-mei, Shen, Shanwei, Qiao, Li-Ya
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3498573/
https://ncbi.nlm.nih.gov/pubmed/22921460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2012.08.007
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