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Isolated Toll-like Receptor Transmembrane Domains Are Capable of Oligomerization

Toll-like receptors (TLRs) act as the first line of defense against bacterial and viral pathogens by initiating critical defense signals upon dimer activation. The contribution of the transmembrane domain in the dimerization and signaling process has heretofore been overlooked in favor of the extrac...

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Autors principals: Godfroy, James I., Roostan, Mohammad, Moroz, Yurii S., Korendovych, Ivan V., Yin, Hang
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3498381/
https://ncbi.nlm.nih.gov/pubmed/23155421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0048875
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