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Advantages and limitations of cell-based assays for GTPase activation and regulation

Small GTPases of the Ras superfamily are important regulators of many cellular functions, including signal transduction, cytoskeleton assembly, metabolic regulation, organelle biogenesis and intracellular transport. Most GTPases act as binary switches, being “on” in the active, GTP-bound state and “...

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Detalles Bibliográficos
Autor Principal: Casanova, James E.
Formato: Artigo
Idioma:Inglês
Publicado: Landes Bioscience 2012
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3498073/
https://ncbi.nlm.nih.gov/pubmed/23181197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cl.22045
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