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Apo-intermediate in the transport cycle of lactose permease (LacY)

The lactose permease (LacY) catalyzes coupled stoichiometric symport of a galactoside and an H(+). Crystal structures reveal 12, mostly irregular, transmembrane α-helices surrounding a cavity with sugar- and H(+)- binding sites at the apex, which is accessible from the cytoplasm and sealed on the pe...

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Autors principals: Madej, M. Gregor, Soro, Sonya N., Kaback, H. Ronald
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3497813/
https://ncbi.nlm.nih.gov/pubmed/23012238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1211183109
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