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Candidate autism gene screen identifies critical role for cell-adhesion molecule CASPR2 in dendritic arborization and spine development

Mutations in the contactin-associated protein 2 (CNTNAP2) gene encoding CASPR2, a neurexin-related cell-adhesion molecule, predispose to autism, but the function of CASPR2 in neural circuit assembly remains largely unknown. In a knockdown survey of autism candidate genes, we found that CASPR2 is req...

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Detalhes bibliográficos
Main Authors: Anderson, Garret R., Galfin, Timothy, Xu, Wei, Aoto, Jason, Malenka, Robert C., Südhof, Thomas C.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3497786/
https://ncbi.nlm.nih.gov/pubmed/23074245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1216398109
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