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Simple few-state models reveal hidden complexity in protein folding
Markov state models constructed from molecular dynamics simulations have recently shown success at modeling protein folding kinetics. Here we introduce two methods, flux PCCA+ (FPCCA+) and sliding constraint rate estimation (SCRE), that allow accurate rate models from protein folding simulations. We...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3497769/ https://ncbi.nlm.nih.gov/pubmed/22778442 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1201810109 |
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