Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines

GABA(A) receptors are pentameric ligand-gated ion channels involved in fast inhibitory neurotransmission and are allosterically modulated by the anxiolytic, anticonvulsant, and sedative-hypnotic benzodiazepines. Here we show that the prokaryotic homolog ELIC also is activated by GABA and is modulate...

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Hlavní autoři: Spurny, Radovan, Ramerstorfer, Joachim, Price, Kerry, Brams, Marijke, Ernst, Margot, Nury, Hugues, Verheij, Mark, Legrand, Pierre, Bertrand, Daniel, Bertrand, Sonia, Dougherty, Dennis A., de Esch, Iwan J. P., Corringer, Pierre-Jean, Sieghart, Werner, Lummis, Sarah C. R., Ulens, Chris
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2012
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PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3497736/
https://ncbi.nlm.nih.gov/pubmed/23035248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1208208109
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