Genome-Wide Analyses of Zta Binding to the Epstein-Barr Virus Genome Reveals Interactions in both Early and Late Lytic Cycles and an Epigenetic Switch Leading to an Altered Binding Profile

The Epstein-Barr virus (EBV) genome sustains substantial epigenetic modification involving chromatin remodelling and DNA methylation during lytic replication. Zta (ZEBRA, BZLF1), a key regulator of the EBV lytic cycle, is a transcription and replication factor, binding to Zta response elements (ZREs...

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Detalhes bibliográficos
Main Authors: Ramasubramanyan, Sharada, Kanhere, Aditi, Osborn, Kay, Flower, Kirsty, Jenner, Richard G., Sinclair, Alison J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3497672/
https://ncbi.nlm.nih.gov/pubmed/23015699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01705-12
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