Structure of Hepatitis C Virus Envelope Glycoprotein E2 Antigenic Site 412 to 423 in Complex with Antibody AP33

We have determined the crystal structure of the broadly neutralizing antibody (bnAb) AP33, bound to a peptide corresponding to hepatitis C virus (HCV) E2 envelope glycoprotein antigenic site 412 to 423. Comparison with bnAb HCV1 bound to the same epitope reveals a different angle of approach to the...

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Bibliographic Details
Main Authors: Kong, Leopold, Giang, Erick, Nieusma, Travis, Robbins, Justin B., Deller, Marc C., Stanfield, Robyn L., Wilson, Ian A., Law, Mansun
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2012
Subjects:
Vaccines and Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3497658/
https://ncbi.nlm.nih.gov/pubmed/22973046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01939-12
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