Toward a Hepatitis C Virus Vaccine: the Structural Basis of Hepatitis C Virus Neutralization by AP33, a Broadly Neutralizing Antibody

The E2 envelope glycoprotein of hepatitis C virus (HCV) binds to the host entry factor CD81 and is the principal target for neutralizing antibodies (NAbs). Most NAbs recognize hypervariable region 1 on E2, which undergoes frequent mutation, thereby allowing the virus to evade neutralization. Consequ...

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Autors principals: Potter, Jane A., Owsianka, Ania M., Jeffery, Nathan, Matthews, David J., Keck, Zhen-Yong, Lau, Patrick, Foung, Steven K. H., Taylor, Garry L., Patel, Arvind H.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2012
Matèries:
Vaccines and Antiviral Agents
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3497650/
https://ncbi.nlm.nih.gov/pubmed/22993159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02052-12
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