Characterization of Conserved Region 2-Deficient Mutants of the Cytomegalovirus Egress Protein pM53

Dominant-negative (DN) mutants are powerful tools for studying essential protein-protein interactions. A systematic genetic screen of the essential murine cytomegalovirus (MCMV) protein pM53 identified the accumulation of inhibitory mutations within conserved region 2 (CR2) and CR4. The strong inhib...

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Main Authors: Pogoda, Madlen, Bosse, Jens B., Wagner, Felicia M., Schauflinger, Martin, Walther, Paul, Koszinowski, Ulrich H., Ruzsics, Zsolt
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2012
Teme:
Virus-Cell Interactions
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3497646/
https://ncbi.nlm.nih.gov/pubmed/22993161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00471-12
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