Double-Stranded RNA Induces Biphasic STAT1 Phosphorylation by both Type I Interferon (IFN)-Dependent and Type I IFN-Independent Pathways

Upon viral infection, pattern recognition receptors sense viral nucleic acids, leading to the production of type I interferons (IFNs), which initiate antiviral activities. Type I IFNs bind to their cognate receptor, IFNAR, resulting in the activation of signal-transducing activators of transcription...

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Detalhes bibliográficos
Main Authors: Dempoya, Junichi, Matsumiya, Tomoh, Imaizumi, Tadaatsu, Hayakari, Ryo, Xing, Fei, Yoshida, Hidemi, Okumura, Ken, Satoh, Kei
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Cellular Response to Infection
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3497619/
https://ncbi.nlm.nih.gov/pubmed/22973045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01881-12
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