Dosing Nomograms for Attaining Optimum Concentrations of Meropenem by Continuous Infusion in Critically Ill Patients with Severe Gram-Negative Infections: a Pharmacokinetics/Pharmacodynamics-Based Approach

The worrisome increase in Gram-negative bacteria with borderline susceptibility to carbapenems and of carbapenemase-producing Enterobacteriaceae has significantly undermined their efficacy. Continuous infusion may be the best way to maximize the time-dependent activity of meropenem. The aim of this...

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Autores principales: Pea, Federico, Viale, Pierluigi, Cojutti, Piergiorgio, Furlanut, Mario
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2012
Materias:
Clinical Therapeutics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3497191/
https://ncbi.nlm.nih.gov/pubmed/23045356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01291-12
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