Comparison of the In Vivo Pharmacokinetics and In Vitro Dissolution of Raltegravir in HIV Patients Receiving the Drug by Swallowing or by Chewing

The pharmacokinetics of raltegravir (RAL) in HIV patients is characterized by high interpatient/intrapatient variability. We investigated the potential contribution of the drug pharmaceutical formulation to RAL pharmacokinetics. We first compared in vivo the pharmacokinetics of RAL for 67 patients t...

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Bibliographic Details
Main Authors: Cattaneo, Dario, Baldelli, Sara, Cerea, Matteo, Landonio, Simona, Meraviglia, Paola, Simioni, Emanuela, Cozzi, Valeria, Fucile, Serena, Gazzaniga, Andrea, Clementi, Emilio, Galli, Massimo, Rizzardini, Giuliano, Gervasoni, Cristina
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2012
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3497176/
https://ncbi.nlm.nih.gov/pubmed/22964253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00942-12
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