Functionally Suppressive CD8 T Regulatory Cells Are Increased in Patients with Multiple Myeloma: A Cause for Immune Impairment

BACKGROUND: Multiple myeloma (MM) is a plasma cell malignancy frequently associated with impaired immune cell numbers and functions. In MM, several studies have previously shown that CD4 regulatory T (Treg) cells hamper effector T cell functions and enhance immune dysfunction. In this study, we aime...

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Detalhes bibliográficos
Main Authors: Muthu Raja, Karthick Raja, Kubiczkova, Lenka, Rihova, Lucie, Piskacek, Martin, Vsianska, Pavla, Hezova, Renata, Pour, Ludek, Hajek, Roman
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3496705/
https://ncbi.nlm.nih.gov/pubmed/23152910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0049446
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