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Gene deletions in alpha thalassemia prove that the 5' zeta locus is functional.

The deletions in the zeta-alpha globin gene cluster in two infants with the hemoglobin Bart's hydrops fetalis syndrome (homozygous alpha thalassemia 1) have been mapped by restriction endonuclease analysis using a zeta-specific probe. DNA from a Thai infant lacked the psi alpha 1 gene and both alpha...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Pressley, L, Higgs, D R, Clegg, J B, Weatherall, D J
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1980
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC349662/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6158051/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.77.6.3586
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