Regulation of in vitro human T cell development through interleukin-7 deprivation and anti-CD3 stimulation

BACKGROUND: The role of IL-7 and pre-TCR signaling during T cell development has been well characterized in murine but not in human system. We and others have reported that human BM hematopoietic progenitor cells (HPCs) display poor proliferation, inefficient double negative (DN) to double positive...

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Detalhes bibliográficos
Main Authors: Patel, Ekta S, Okada, Starlyn, Hachey, Kevin, Yang, Li-jun, Durum, Scott K, Moreb, Jan S, Chang, Lung-Ji
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3496569/
https://ncbi.nlm.nih.gov/pubmed/22897934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2172-13-46
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