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Direct Observation of Cotranscriptional Folding in an Adenine Riboswitch
Growing RNA chains fold cotranscriptionally as they are synthesized by RNA polymerase (RNAP). Riboswitches, which regulate gene expression by adopting alternative RNA folds, are sensitive to cotranscriptional events. We developed an optical-trapping assay to follow the cotranscriptional folding of a...
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| Autores principales: | , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3496414/ https://ncbi.nlm.nih.gov/pubmed/23087247 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1225722 |
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