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Enabling the Intestinal Absorption of Highly Polar Anti-Viral Agents: Ion-Pair Facilitated Membrane Permeation of Zanamivir Heptyl Ester and Guanidino Oseltamivir
Anti-viral drugs often suffer from poor intestinal permeability, preventing their delivery via the oral route. The goal of this work was to enhance the intestinal absorption of the low-permeability anti-viral agents zanamivr heptyl ester (ZHE) and guanidino oseltamivir (GO) utilizing an ion-pairing...
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| Main Authors: | , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2010
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3496398/ https://ncbi.nlm.nih.gov/pubmed/20536260 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp100050d |
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