Metabolomics identifies an inflammatory cascade involved in dioxin- and diet-induced steatohepatitis

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is among the most potent environmentally toxic compounds. Serum metabolomics identified azelaic acid-mono esters as significantly increased metabolites after TCDD treatment, due to down-regulation of hepatic carboxylesterase 3 (CES3, also known as triglycer...

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Autors principals: Matsubara, Tsutomu, Tanaka, Naoki, Krausz, Kristopher W., Manna, Soumen K., Kang, Dong Wook, Anderson, Erik R., Luecke, Hans, Patterson, Andrew D., Shah, Yatrik M., Gonzalez, Frank J.
Format: Artigo
Idioma:Inglês
Publicat: 2012
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3496181/
https://ncbi.nlm.nih.gov/pubmed/23140643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2012.10.006
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