Differential Regulation of Amyloid Precursor Protein/Presenilin 1 Interaction during Ab40/42 Production Detected Using Fusion Constructs

Beta amyloid peptides (Aβ) play a key role in the pathogenesis of Alzheimer disease (AD). Presenilins (PS) function as the catalytic subunits of γ-secretase, the enzyme that releases Aβ from ectodomain cleaved amyloid precursor protein (APP) by intramembrane proteolysis. Familial Alzheimer disease (...

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Detalhes bibliográficos
Main Authors: Sato, Naoyuki, Okochi, Masayasu, Shinohara, Mitsuru, Thinakaran, Gopal, Takeda, Shuko, Fukumori, Akio, Shinohara-Noma, Motoko, Mori-Ueda, Mari, Hamada, Hizuki, Takeda, Masatoshi, Rakugi, Hiromi, Morishita, Ryuichi
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3495957/
https://ncbi.nlm.nih.gov/pubmed/23152781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0048551
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