Rbf1 degron dysfunction enhances cellular DNA replication

The E2F family of transcription factors contributes to oncogenesis through activation of multiple genes involved in cellular proliferation, a process that is opposed by the Retinoblastoma tumor suppressor protein (RB). RB also increases E2F1 stability by inhibiting its proteasome-mediated degradatio...

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Bibliographic Details
Main Authors: Raj, Nitin, Zhang, Liang, Wei, Yiliang, Arnosti, David N., Henry, R. William
Format: Artigo
Language:Inglês
Published: Landes Bioscience 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3495815/
https://ncbi.nlm.nih.gov/pubmed/22895052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.21665
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