Population PK/PD analysis of metformin using the signal transduction model

AIMS: To develop a population pharmacokinetic (PK) and pharmacodynamic (PD) model for metformin (500 mg) using the signal transduction model in healthy humans and to predict the PK/PD profile in patients with type 2 diabetes. METHODS: Following the oral administration of 500 mg metformin to healthy...

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Detalhes bibliográficos
Main Authors: Chae, Jung-woo, Baek, In-hwan, Lee, Byung-yo, Cho, Seong-kwon, Kwon, Kwang-il
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2012
Assuntos:
Pharmacokinetic Dynamic Relationships
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3495146/
https://ncbi.nlm.nih.gov/pubmed/22380769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2012.04260.x
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