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Population PK–PD analyses of CD25 occupancy, CD56(bright) NK cell expansion, and regulatory T cell reduction by daclizumab HYP in subjects with multiple sclerosis
AIM: Daclizumab high yield process (HYP) is a humanized IgG1 monoclonal antibody that binds to the α‐subunit of the interleukin‐2 receptor and is being developed for treatment of multiple sclerosis (MS). This manuscript characterized the pharmacokinetic–pharmacodynamic (PK–PD) relationships of dacli...
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| Publicado no: | Br J Clin Pharmacol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5061794/ https://ncbi.nlm.nih.gov/pubmed/27333593 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13051 |
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