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Prenatal diagnosis of sickle cell anemia by restriction and endonuclease analysis: HindIII polymorphisms in gamma-globin genes extend test applicability.

Polymorphism for a Hpa I restriction endonuclease site associated with about 60% of beta S genes in American Blacks allows exact prenatal diagnosis of sickle cell anemia by amniocentesis in 36% of couples at risk. In three families in whom exact diagnosis by Hpa I sites was impossible, we found anal...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Phillips, J A, Panny, S R, Kazazian, H H, Boehm, C D, Scott, A F, Smith, K D
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 1980
Témata:
On-line přístup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC349503/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6248872/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.77.5.2853
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