Gene-directed mutagenesis in bacteriophage T7 provided by polyalkylating RNAs complementary to selected DNA sites.

Bacteriophage T7 early transcripts were used as carriers of alkylating groups to affect complementary T7 DNA sites for inducing mutations in preselected genes. A heterofunctional polyalkylating agent N,N,N'-tri-(beta-chloroethyl)-N'-(p-formylphenyl)propylene diamine-1,3 was attached to 3-5...

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Autores principales: Salganik, R I, Dianov, G L, Ovchinnikova, L P, Voronina, E N, Kokoza, E B, Mazin, A V
Formato: Artigo
Lenguaje:Inglês
Publicado: 1980
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC349491/
https://ncbi.nlm.nih.gov/pubmed/6930667
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