Gene-directed mutagenesis in bacteriophage T7 provided by polyalkylating RNAs complementary to selected DNA sites.

Bacteriophage T7 early transcripts were used as carriers of alkylating groups to affect complementary T7 DNA sites for inducing mutations in preselected genes. A heterofunctional polyalkylating agent N,N,N'-tri-(beta-chloroethyl)-N'-(p-formylphenyl)propylene diamine-1,3 was attached to 3-5...

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Main Authors: Salganik, R I, Dianov, G L, Ovchinnikova, L P, Voronina, E N, Kokoza, E B, Mazin, A V
格式: Artigo
語言:Inglês
出版: 1980
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC349491/
https://ncbi.nlm.nih.gov/pubmed/6930667
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