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Development of proteasome inhibitors as research tools and cancer drugs
The proteasome is the primary site for protein degradation in mammalian cells, and proteasome inhibitors have been invaluable tools in clarifying its cellular functions. The anticancer agent bortezomib inhibits the major peptidase sites in the proteasome’s 20S core particle. It is a “blockbuster dru...
Uloženo v:
| Hlavní autor: | |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
The Rockefeller University Press
2012
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3494858/ https://ncbi.nlm.nih.gov/pubmed/23148232 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201210077 |
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