Galectin-3 Impairment of MYCN-Dependent Apoptosis-Sensitive Phenotype Is Antagonized by Nutlin-3 in Neuroblastoma Cells

MYCN amplification occurs in about 20–25% of human neuroblastomas and characterizes the majority of the high-risk cases, which display less than 50% prolonged survival rate despite intense multimodal treatment. Somehow paradoxically, MYCN also sensitizes neuroblastoma cells to apoptosis, understandi...

Full description

Saved in:
Bibliographic Details
Main Authors: Veschi, Veronica, Petroni, Marialaura, Cardinali, Beatrice, Dominici, Carlo, Screpanti, Isabella, Frati, Luigi, Bartolazzi, Armando, Gulino, Alberto, Giannini, Giuseppe
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3494673/
https://ncbi.nlm.nih.gov/pubmed/23152863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0049139
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items