SAMHD1 restricts HIV-1 reverse transcription in quiescent CD4(+) T-cells

BACKGROUND: Quiescent CD4(+) T lymphocytes are highly refractory to HIV-1 infection due to a block at reverse transcription. RESULTS: Examination of SAMHD1 expression in peripheral blood lymphocytes shows that SAMHD1 is expressed in both CD4+ and CD8+ T cells at levels comparable to those found in m...

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Main Authors: Descours, Benjamin, Cribier, Alexandra, Chable-Bessia, Christine, Ayinde, Diana, Rice, Gillian, Crow, Yanick, Yatim, Ahmad, Schwartz, Olivier, Laguette, Nadine, Benkirane, Monsef
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2012
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3494655/
https://ncbi.nlm.nih.gov/pubmed/23092122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-9-87
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