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Dual Roles of MDM2 in the Regulation of p53: Ubiquitination Dependent and Ubiquitination Independent Mechanisms of MDM2 Repression of p53 Activity
MDM2 oncogenic protein is the principal cellular antagonist of the p53 tumor suppresser gene. p53 activity needs exquisite control to elicit appropriate responses to differential cellular stress conditions. p53 becomes stabilized and active upon various types of stresses. However, too much p53 is no...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
SAGE Publications
2012
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3494363/ https://ncbi.nlm.nih.gov/pubmed/23150757 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1947601912455199 |
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