Total ApoE and ApoE4 Isoform Assays in an Alzheimer's Disease Case-control Study by Targeted Mass Spectrometry (n = 669): A Pilot Assay for Methionine-containing Proteotypic Peptides

Allelic polymorphism of the apolipoprotein E (ApoE) gene (ApoE ε2, ApoE ε3 and ApoE ε4 alleles) gives rise to three protein isoforms (ApoE2, ApoE3 and ApoE4) that differ by 1 or 2 amino acids. Inheritance of the ApoE ε4 allele is a risk factor for developing Alzheimer's disease (AD). The potent...

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Bibliografiske detaljer
Main Authors: Simon, Romain, Girod, Marion, Fonbonne, Catherine, Salvador, Arnaud, Clément, Yohann, Lantéri, Pierre, Amouyel, Philippe, Lambert, Jean Charles, Lemoine, Jérôme
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Biochemistry and Molecular Biology 2012
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3494189/
https://ncbi.nlm.nih.gov/pubmed/22918225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M112.018861
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