The Amyloid Precursor Protein (APP) Family Members are Key Players in S-adenosylmethionine Formation by MAT2A and Modify BACE1 and PSEN1 Gene Expression-Relevance for Alzheimer's Disease

Central hallmark of Alzheimer's disease are senile plaques mainly composed of β-amyloid, which is a cleavage product of the amyloid precursor protein (APP). The physiological function of APP and its family members APLP1 and APLP2 is poorly understood. In order to fill this gap, we established a...

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Bibliografische gegevens
Hoofdauteurs: Schrötter, Andreas, Pfeiffer, Kathy, El Magraoui, Fouzi, Platta, Harald W., Erdmann, Ralf, Meyer, Helmut E., Egensperger, Rupert, Marcus, Katrin, Müller, Thorsten
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The American Society for Biochemistry and Molecular Biology 2012
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Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3494178/
https://ncbi.nlm.nih.gov/pubmed/22879628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M112.019364
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