The Amyloid Precursor Protein (APP) Family Members are Key Players in S-adenosylmethionine Formation by MAT2A and Modify BACE1 and PSEN1 Gene Expression-Relevance for Alzheimer's Disease

Central hallmark of Alzheimer's disease are senile plaques mainly composed of β-amyloid, which is a cleavage product of the amyloid precursor protein (APP). The physiological function of APP and its family members APLP1 and APLP2 is poorly understood. In order to fill this gap, we established a...

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Detalhes bibliográficos
Main Authors: Schrötter, Andreas, Pfeiffer, Kathy, El Magraoui, Fouzi, Platta, Harald W., Erdmann, Ralf, Meyer, Helmut E., Egensperger, Rupert, Marcus, Katrin, Müller, Thorsten
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3494178/
https://ncbi.nlm.nih.gov/pubmed/22879628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M112.019364
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