A 22-mer Segment in the Structurally Pliable Regulatory Domain of Metazoan CTP: Phosphocholine Cytidylyltransferase Facilitates Both Silencing and Activating Functions

CTP:phosphocholine cytidylyltransferase (CCT), an amphitropic enzyme that regulates phosphatidylcholine synthesis, is composed of a catalytic head domain and a regulatory tail. The tail region has dual functions as a regulator of membrane binding/enzyme activation and as an inhibitor of catalysis in...

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Detalhes bibliográficos
Main Authors: Ding, Ziwei, Taneva, Svetla G., Huang, Harris K. H., Campbell, Stephanie A., Semenec, Lucie, Chen, Nansheng, Cornell, Rosemary B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3493939/
https://ncbi.nlm.nih.gov/pubmed/22988242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.402081
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