Bicalutamide-induced hypoxia potentiates RUNX2-mediated Bcl-2 expression resulting in apoptosis resistance

BACKGROUND: We have previously shown that hypoxia selects for more invasive, apoptosis-resistant LNCaP prostate cancer cells, with upregulation of the osteogenic transcription factor RUNX2 and the anti-apoptotic factor Bcl-2 detected in the hypoxia-selected cells. Following this observation, we ques...

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Bibliographic Details
Main Authors: Browne, G, Nesbitt, H, Ming, L, Stein, G S, Lian, J B, McKeown, S R, Worthington, J
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2012
Subjects:
Molecular Diagnostics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3493869/
https://ncbi.nlm.nih.gov/pubmed/23073173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2012.455
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