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Structure of a bacterial voltage-gated sodium channel pore reveals mechanisms of opening and closing
Voltage-gated sodium channels are vital membrane proteins essential for electrical signalling; in humans, they are key targets for the development of pharmaceutical drugs. Here we report the crystal structure of an open-channel conformation of NavMs, the bacterial channel pore from the marine bacter...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Pub. Group
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3493636/ https://ncbi.nlm.nih.gov/pubmed/23033078 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2077 |
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