Activation of Haem-Oxidized Soluble Guanylyl Cyclase with BAY 60-2770 in Human Platelets Lead to Overstimulation of the Cyclic GMP Signaling Pathway

BACKGROUND AND AIMS: Nitric oxide-independent soluble guanylyl cyclase (sGC) activators reactivate the haem-oxidized enzyme in vascular diseases. This study was undertaken to investigate the anti-platelet mechanisms of the haem-independent sGC activator BAY 60-2770 in human washed platelets. The hyp...

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Main Authors: Mendes-Silverio, Camila B., Leiria, Luiz O. S., Morganti, Rafael P., Anhê, Gabriel F., Marcondes, Sisi, Mónica, Fabíola Z., De Nucci, Gilberto, Antunes, Edson
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2012
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3493568/
https://ncbi.nlm.nih.gov/pubmed/23144808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0047223
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