Informed Conditioning on Clinical Covariates Increases Power in Case-Control Association Studies

Genetic case-control association studies often include data on clinical covariates, such as body mass index (BMI), smoking status, or age, that may modify the underlying genetic risk of case or control samples. For example, in type 2 diabetes, odds ratios for established variants estimated from low–...

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Main Authors: Zaitlen, Noah, Lindström, Sara, Pasaniuc, Bogdan, Cornelis, Marilyn, Genovese, Giulio, Pollack, Samuela, Barton, Anne, Bickeböller, Heike, Bowden, Donald W., Eyre, Steve, Freedman, Barry I., Friedman, David J., Field, John K., Groop, Leif, Haugen, Aage, Heinrich, Joachim, Henderson, Brian E., Hicks, Pamela J., Hocking, Lynne J., Kolonel, Laurence N., Landi, Maria Teresa, Langefeld, Carl D., Le Marchand, Loic, Meister, Michael, Morgan, Ann W., Raji, Olaide Y., Risch, Angela, Rosenberger, Albert, Scherf, David, Steer, Sophia, Walshaw, Martin, Waters, Kevin M., Wilson, Anthony G., Wordsworth, Paul, Zienolddiny, Shanbeh, Tchetgen, Eric Tchetgen, Haiman, Christopher, Hunter, David J., Plenge, Robert M., Worthington, Jane, Christiani, David C., Schaumberg, Debra A., Chasman, Daniel I., Altshuler, David, Voight, Benjamin, Kraft, Peter, Patterson, Nick, Price, Alkes L.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3493452/
https://ncbi.nlm.nih.gov/pubmed/23144628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003032
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