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Somatic diversification is required to generate the V kappa genes of MOPC 511 and MOPC 167 myeloma proteins.

The immune response to phosphocholine in BALB/c mice involves one group of heavy chain variable region (VH) genes and at least three groups of light chain variable region (V kappa) genes, represented by the gene products of the myelomas TEPC 15, MOPC 603, and MOPC 167/MOPC 511. The amino acid sequen...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Gershenfeld, H K, Tsukamoto, A, Weissman, I L, Joho, R
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1981
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC349332/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6801657/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.78.12.7674
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