Down syndrome fibroblasts are hyperresponsive to beta-adrenergic stimulation.

The hormonal response to human skin fibroblasts after exposure to beta-adrenergic agonists, prostaglandin E1 (PGE1), and cholera toxin was monitored by intracellular cyclic AMP accumulation. Down syndrome (DS; trisomy 21) cells had an approximately 10-fold greater response to beta-adrenergic agonist...

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Bibliographic Details
Main Authors: McSwigan, J D, Hanson, D R, Lubiniecki, A, Heston, L L, Sheppard, J R
Format: Artigo
Language:Inglês
Published: 1981
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC349331/
https://ncbi.nlm.nih.gov/pubmed/6278485
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