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Effects of the Iowa and Milano Mutations on Apolipoprotein A-I Structure and Dynamics Determined by Hydrogen Exchange and Mass Spectrometry
The Iowa point mutation in apolipoprotein A-I (G26R; apoA-I(Iowa)) leads to a systemic amyloidosis condition and the Milano mutation (R173C; apoA-I(Mil)) is associated with hypoalphalipoproteinemia, a reduced plasma level of high density lipoprotein. To probe the structural effects that lead to thes...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3493162/ https://ncbi.nlm.nih.gov/pubmed/23066790 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi300926j |
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