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Apolipoprotein A-I helical structure and stability in discoidal high-density lipoprotein (HDL) particles by hydrogen exchange and mass spectrometry

To understand high-density lipoprotein (HDL) structure at the molecular level, the location and stability of α-helical segments in human apolipoprotein (apo) A-I in large (9.6 nm) and small (7.8 nm) discoidal HDL particles were determined by hydrogen-deuterium exchange (HX) and mass spectrometry met...

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Detalhes bibliográficos
Main Authors: Sevugan Chetty, Palaniappan, Mayne, Leland, Kan, Zhong-Yuan, Lund-Katz, Sissel, Englander, S. Walter, Phillips, Michael C.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3406875/
https://ncbi.nlm.nih.gov/pubmed/22745166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1209305109
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