Glyoxylate carboligase: a unique thiamin diphosphate-dependent enzyme that can cycle between the 4′-aminopyrimidinium and the 1′,4′-iminopyrimidine tautomeric forms in the absence of the conserved glutamate

Glyoxylate carboligase (GCL) is a thiamin diphosphate (ThDP)-dependent enzyme, which catalyzes the decarboxylation of glyoxylate and ligation to a second molecule of glyoxylate to form tartronate semialdehyde (TSA). This enzyme is unique among ThDP enzymes in that it lacks a conserved glutamate near...

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Detalhes bibliográficos
Main Authors: Nemeria, Natalia, Binshtein, Elad, Patel, Hetalben, Balakrishnan, Anand, Vered, Ilan, Shaanan, Boaz, Barak, Ze’ev, Chipman, David, Jordan, Frank
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3493109/
https://ncbi.nlm.nih.gov/pubmed/22970650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi300893v
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