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A Stabilized Respiratory Syncytial Virus Reverse Genetics System Amenable to Recombination Mediated Mutagenesis

We describe the first example of combining bacterial artificial chromosome (BAC) recombination-mediated mutagenesis with reverse genetics for a negative strand RNA virus. A BAC-based respiratory syncytial virus (RSV) rescue system was established. An important advantage of this system is that RSV an...

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Detalhes bibliográficos
Main Authors: Hotard, Anne L., Shaikh, Fyza Y., Lee, Sujin, Yan, Dan, Teng, Michael N., Plemper, Richard K., Crowe, James E., Moore, Martin L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3492879/
https://ncbi.nlm.nih.gov/pubmed/23062737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2012.09.022
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