ROCK/Cdc42-mediated microglial motility and gliapse formation lead to phagocytosis of degenerating dopaminergic neurons in vivo

The role of microglial motility in the context of adult neurodegeneration is poorly understood. In the present work, we investigated the microanatomical details of microglia-neuron interactions in an experimental mouse model of Parkinson's disease following the intraperitoneal injection of MPTP...

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Main Authors: Barcia, Carlos, Ros, Carmen María, Annese, Valentina, Carrillo-de Sauvage, María Angeles, Ros-Bernal, Francisco, Gómez, Aurora, Yuste, José Enrique, Campuzano, Carmen María, de Pablos, Vicente, Fernandez-Villalba, Emiliano, Herrero, María Trinidad
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3492875/
https://ncbi.nlm.nih.gov/pubmed/23139861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep00809
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