ROCK/Cdc42-mediated microglial motility and gliapse formation lead to phagocytosis of degenerating dopaminergic neurons in vivo

The role of microglial motility in the context of adult neurodegeneration is poorly understood. In the present work, we investigated the microanatomical details of microglia-neuron interactions in an experimental mouse model of Parkinson's disease following the intraperitoneal injection of MPTP...

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Detalhes bibliográficos
Main Authors: Barcia, Carlos, Ros, Carmen María, Annese, Valentina, Carrillo-de Sauvage, María Angeles, Ros-Bernal, Francisco, Gómez, Aurora, Yuste, José Enrique, Campuzano, Carmen María, de Pablos, Vicente, Fernandez-Villalba, Emiliano, Herrero, María Trinidad
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3492875/
https://ncbi.nlm.nih.gov/pubmed/23139861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep00809
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